Comparative Effectiveness and Safety of Cefdinir and Amoxicillin-Clavulanate in Treatment of Acute Community-Acquired Bacterial Sinusitis
نویسندگان
چکیده
JACK M. GWALTNEY, JR.,* S. SAVOLAINEN, P. RIVAS, P. SCHENK, W. MICHAEL SCHELD, AUSTIN SYDNOR, CONSTANCE KEYSERLING, A. LEIGH, KENNETH J. TACK, AND THE CEFDINIR SINUSITIS STUDY GROUP† Department of Internal Medicine, University of Virginia Health Science Center, Charlottesville, Virginia 22908; Department of ORL, Central Military Hospital, Helsinki, Finland; Provenza, 50 1 2a, 08901 L’Hospitalet de Llobregat, Barcelona, Spain; University Klinik für HNO-Krankheiten, Vienna, Austria; Parke-Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105; and Parke-Davis Pharmaceutical Research, Freiburg, Germany
منابع مشابه
Comparative effectiveness and safety of cefdinir and amoxicillin-clavulanate in treatment of acute community-acquired bacterial sinusitis. Cefdinir Sinusitis Study Group.
Cefdinir is an extended-spectrum oral cephalosporin that is active against pathogens commonly seen in acute community-acquired bacterial sinusitis (ACABS), including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Two randomized, investigator-blind, multicenter trials (one in the United States and one in Europe) compared two dosage regimens of cefdinir (600 mg once ...
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OBJECTIVE To compare the safety and efficacy of a combination of amoxicillin and clavulanate potassium given orally every 12 hours (amoxicillin, 875 mg; clavulanate, 125 mg) with that given every 8 hours (amoxicillin, 500 mg; clavulanate, 125 mg) for the treatment of patients with acute bacterial maxillary sinusitis. DESIGN Multicenter double-blind randomized double-dummy controlled trial. ...
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A randomized, double-blind, multicenter study of adults with acute bacterial sinusitis (ABS) compared the efficacy and safety of two azithromycin (AZM) regimens, 500 mg/day once daily for 3 days (AZM-3) or 6 days (AZM-6) to the efficacy and safety of an amoxicillin-clavulanate (AMC) regimen of 500-125 mg three times daily for 10 days. A total of 936 subjects with clinically and radiologically d...
متن کاملPharmacoeconomic analysis of selected antibiotics in lower respiratory tract infection.
An interactive pharmacoeconomic model was designed to evaluate the effects of clinical response and adverse drug events on the comparative cost and cost-effectiveness of a relatively new antibiotic, clarithromycin, compared with those of six other antibiotics used to treat community-acquired lower respiratory tract infection. The cost and cost-effectiveness analyses were based don 12 randomized...
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تاریخ انتشار 1997